Neural plasticity, Learning and Memory
N6-methyladenosine (m6A), the most prevalent internal RNA modification on mammalian messenger RNAs, regulates the fates and functions of modified transcripts through its specific binding proteins. In the nervous system, m6A is abundant and modulates various neural functions. Our previous work identifies YTHDF1 as a key regulator to facilitate hippocampus-dependent learning and memory. YTHDF1 promotes translation of m6A-modified transcripts related to synaptic transmission and LTP, in response to learning stimulus, thus facilitating synapse strength adequately for a memory to occur. We are conducting systemic study to understand the effect of other m6A modulators in regulating learning behaviors.