How m6A affects mental disorders?
Depression (major depressive disorder) is a common and serious mental disorder that negatively affects how you feel, think, act, and perceive the world. Nearly three in ten adults (29%) have been diagnosed with depression at some point in their lives and about 18% are currently experiencing depression. As a new post-transcriptional regulation pathway, m6A affects a lot of biological processes. Whereas the exact role of m6A in mental disorders, such as depression, is largely unknown. Combining RNA/m6A-seq, proteomic analysis, genetic mouse model, behavioral assay, and electro-physiological recording, we are investigating the mechanism of how m6A was participated in the pathophysiology of depression.